Aptamer‐functionalized Ti ₃ C ₂ ‐MXene Nanosheets with One‐step Potentiometric Detection of Programmed Death‐ligand 1

This communication describes a simple sensitive one-step potentiometric aptasensing method for quantitative detection of referenced therapeutic biomarker (programmed death-ligand 1, PD−L1). The aptasensor is constructed by modifying PD−L1-specific aptamer on Ti3C2-MXene nanosheets-functionalized electrode. Introduction PD−L1 induces the specific reaction between and aptamer, thereby resulting in change spatial structures. surface electric potential modified electrode shifted upon addition proteins before after with analyte. Interestingly, nanosheets can achieve higher sensitivity lower limit toward target relative to aptamer-modified Experimental results indicated that linear range using were 0.01–100 ng mL−1 7.8 pg PD−L1, respectively. Meanwhile, specificity, reproducibility, storing stability accuracy are acceptable screening human serum samples.